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Cortisol

C₂₁H₃₀O₅ · 56 atoms

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Cortisol

Elements

About

Cortisol is a 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses. It has a role as an anti-inflammatory drug, an anti-asthmatic drug, an anti-allergic agent, a mouse metabolite, a human metabolite and a drug allergen. It is a 17alpha-hydroxy-C21-steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid and a 3-oxo-Delta(4) steroid. It derives from a hydride of a pregnane.

Properties

IUPAC name(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

CAS number50-23-7

Molar mass362.5 g/mol

Melting point220 °C

GHS hazards

Health hazard

Sources

Properties: PubChem CID 5754
3D structure: PubChem CID 5754 (3D conformer)
CAS number: PubChem CID 5754
Description: PubChem ← ChEBI
Melting point: PubChem ← DrugBank
Hazards: PubChem ← European Chemicals Agency (ECHA)

Data from PubChem (NIH/NLM). Some annotations originate with the upstream sources shown.